| Date | Location | Result | |
| 11/13/10 | Oskaloosa, Iowa | William Penn (IA) 24, St. Francis (IL) 7 | Box score |
| 11/06/10 | Joliet, Ill. | St. Francis (IL) 35, Quincy 3 | Box score |
| 10/30/10 | Joliet, Ill. | St. Francis (IL) 56, Waldorf (IA) 10 | Box score |
| 10/23/10 | Bourbonnais, Ill. | St. Francis (IL) 49, Olivet Nazarene 35 | Box score |
| 10/16/10 | Joliet, Ill. | St. Francis (IL) 61, Haskell Indian (KS) 16 | Box score |
| 10/09/10 | Joliet, Ill. | St. Francis (IL) 28, McKendree 24 | Box score |
| 10/02/10 | Davenport, Iowa | St. Francis (IL) 27, St. Ambrose (IA) 24 | Box score |
| 09/25/10 | Joliet, Ill. | Iowa Wesleyan 24, St. Francis (IL) 21 | Box score |
| 09/11/10 | Joliet, Ill. | St. Francis (IL) 17, Grand View (IA) 10 | Box score |
| 09/02/10 | Chicago, Ill. | Saint Xavier 52, St. Francis (IL) 21 | Box score |
| 08/28/10 | Indianapolis, Ind. | Marian (IN) 37, St. Francis (IL) 17 | Box score |